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reactome-mcp

Enables AI assistants to search, browse, analyze, and export biological pathway data from Reactome through natural language.

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// key findings
⚠️
Known vulnerabilities in dependencies: 3 high
Affects packages this MCP installs at runtime. Upgrade or remove the affected dependency.
No credential exfiltration, no sensitive file access, no obfuscation
Static analysis found nothing flowing your secrets to unexpected places.
Open source with a license and README
Anyone can audit the code, the license is declared, and the publisher documents what it does.
🔐
You'll be asked for 1 credential: NEO4J_PASSWORD
These are read from process.env at runtime. Make sure you trust where they’ll be sent.
// known CVEs in dependencies3 high

Disclosed vulnerabilities in this server's declared npm dependencies (via OSV). Whether each is reachable depends on the installed versions.

high@modelcontextprotocol/sdk@1.12.0GHSA-345p-7cg4-v4c7

@modelcontextprotocol/sdk has cross-client data leak via shared server/transport instance reuse

high@modelcontextprotocol/sdk@1.12.0GHSA-8r9q-7v3j-jr4g

Anthropic's MCP TypeScript SDK has a ReDoS vulnerability

high@modelcontextprotocol/sdk@1.12.0GHSA-w48q-cv73-mx4w

Model Context Protocol (MCP) TypeScript SDK does not enable DNS rebinding protection by default

Depend on this server? Get alerted when its CVEs change.Watch this server free →
// required environment variables
This server reads these from process.env. You'll be asked to provide them before it can run.
configALLOWED_ORIGINS
configCYPHER_QUERY_TIMEOUT_MS30000 Server-side transaction timeout (ms) for reactome_cypher_ tools. Runaway queries are terminated after this.
configLOG_LEVELinfo debug / info / warn / error. Logs are JSON on stderr; stdout is reserved for the MCP protocol.
configNEO4J_DATABASEgraph.db Matches the default in reactome_neo4j_env.
🔐 secretNEO4J_PASSWORDneo4j Works against auth-disabled local images (reactome_neo4j_env). Set explicitly for any remote database.
configNEO4J_URI_(unset)_ Set to enable the optional Cypher tools (see below).
configNEO4J_USER"": "neo4j",
configPORT
configREACTOME_ANALYSIS_SERVICE_URLderived from REACTOME_BASE_URL Fine-grained override for the Analysis Service only.
configREACTOME_BASE_URLREACTOME_CONTENT_SERVICE_URL derived from Fine-grained override for the Content Service only.
configREACTOME_CONTENT_SERVICE_URLderived from REACTOME_BASE_URL Fine-grained override for the Content Service only.
// full audit trail
The full breakdown of what we checked, the deductions that landed, the network hosts, the dependency advisories, and concrete fix guidance is available to verified publishers.
// improvement guidance — verified publishers only
We have 7 concrete improvements we can share with the publisher of this MCP. Each comes with specific guidance to raise the trust score.
// embed badge in your README
[![M8ven Score](https://m8ven.ai/badge/mcp/reactome-reactome-mcp-od348b)](https://m8ven.ai/mcp/reactome-reactome-mcp-od348b)
commit: ee385df5120996442a4cb81d72b16c337cbeff4c
code hash: 2ebee808b7eb3ffd22bf2c3dc7ac7c3582bb976919f02171644511776760b968
verified: 6/22/2026, 1:20:24 PM
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